Accession Number : AD0632282

Title :   DIFFERENTIAL SENSITIVITY OF CIRCULATING AND PERITONEAL MONONUCLEAR CELLS OF MICE TO TOTAL-BODY X IRRADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Kornfeld,Lottie ; Greenman,Vivian

Report Date : 13 MAY 1966

Pagination or Media Count : 18

Abstract : Dose-response curves obtained 1 and 3 days after exposure to total-body X irradiation indicate that the mononuclear cells in the circulating blood and in the peritoneal cavity of LAF sub1 mice may be arranged in the following order of decreasing sensitivity: circulating lymphocytes, small peritoneal lymphocytes, medium peritoneal lymphocytes, peritoneal macrophages. However, on the 3rd day postirradiation, the curve of the small peritoneal lymphocytes closely approached that of the circulating lymphocytes. It is suggested that the greater sensitivity to irradiation of small than of medium peritoneal lymphocytes is not due to environmental factors but to as yet unidentified differences in the cells. On the other hand, the greater loss of circulating lymphocytes than of small peritoneal lymphocytes 1 day after X ray exposure may merely reflect more efficient removal of damaged cells from the circulation than from the peritoneal cavity. (Author)

Descriptors :   (*LYMPHOCYTES, *RADIATION EFFECTS), LEUKOCYTES, X RAYS, PERITONEUM, WHOLE BODY IRRADIATION, PHAGOCYTES, SENSITIVITY, MICE

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE