Accession Number : AD0632540

Title :   EFFECTS OF IRRADIATION ON BONE GROWTH OF RATS DURING PROTRACTED PARABIOSIS,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Carroll,Harold W. ; Phillips,Richard D. ; Kimeldorf,Donald J.

Report Date : 05 APR 1966

Pagination or Media Count : 14

Abstract : The effects of x-irradiation on bone growth were studied in pairs of rats during protracted parabiosis involving vascular anastomosis. The preparation was used to define some potential mechanisms through which systemic factors contribute to growth retardation. No demonstrable deleterious effect of irradiation of one partner was sustained by the shielded partner in terms of bone growth. On the other hand, direct evidence was obtained to show that the bone growth deficit observed in the irradiated rat at 60 days postirradiation was reduced by shielding its parabion partner. The findings are consistent with the concept that the systemic effect on bone growth is a result of hormonal imbalance rather than the consequence of toxic factors produced by irradiation. (Author)

Descriptors :   (*RADIATION EFFECTS, *BONES), (*PARABIOSIS, RADIATION EFFECTS), GROWTH(PHYSIOLOGY), SHIELDING, HORMONES, X RAYS, RATS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE