Accession Number : AD0632954

Title :   SODIUM FLUX AND WATER TRANSPORT IN THE EVERTED RABBIT INTESTINAL SAC,

Corporate Author : NAVAL MEDICAL RESEARCH UNIT NO 2 TAIPEI (TAIWAN)

Personal Author(s) : Neptune,Edgar M. , Jr. ; Mitchell,Thomas G.

Report Date : 02 MAY 1966

Pagination or Media Count : 18

Abstract : The everted intestinal sac prepared from adult rabbit ileum has unidirectional fluxes of sodium that can be measured with Na(22) and Na(24). The rates are linear for one hour. The net flux is from mucosa to serosa and the net values are about 10% of unidirectional fluxes (net, approximately 1 micro Eq/cm sq/hr at 37C, pH 8.0, in Ringer phosphate-bicarbonate). In the same experiments, there is also net transport of water from mucosa to serosa. The sacs consume glucose, but glucose does not stimulate sodium or water transport. Raising the initial potassium concentration of 5 mEq/L to 20 mEq/L increases glucose consumption but does not alter sodium and water transport. The net transport of sodium is inhibited by KCN and HgCl2 and the unidirectional fluxes are decreased but not abolished. (Author)

Descriptors :   (*INTESTINES, SEMIPERMEABILITY), (*ELECTROLYTES(PHYSIOLOGY), SEMIPERMEABILITY), SODIUM, IONS, TRANSPORT PROPERTIES, WATER, POTASSIUM, CHOLERA, MEMBRANES(BIOLOGY), RADIOACTIVE ISOTOPES, TIME STUDIES, GLUCOSE, PH FACTOR, INHIBITION, RABBITS, TAIWAN

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE