Accession Number : AD0634617

Title :   SYNTHESIS AND DEGRADATION OF POLY ALKYL ALPHA CYANOACRYLATES,

Corporate Author : ARMY MEDICAL BIOMECHANICAL RESEARCH LAB WALTER REED ARMY MEDICAL CENTER WASHINGTON D C

Personal Author(s) : Leonard, Fred ; kulkarni,Ramchandra K. ; Brandes,George ; Nelson,Joshua

Report Date : JUN 1966

Pagination or Media Count : 15

Abstract : The capability of rapidly polymerizing monomeric alpha cyanoacrylates to adhere firmly to moist surfaces has evoked considerable medical interest in their potentialities as hemostatic agents and tissue adhesives for closure of wounds in place of, or as adjuncts to, the conventional surgical sutures. A report is given on the synthesis of the homologous series of alkyl-alpha-cyanoacrylates, their physical properties with respect to purity and also the kinetics of in vitro degradation of poly-alkyl-alpha-cyanoacrylates in the presence of water, both in the heterogeneous and homogeneous phases. Other important findings on the mode of polymerization are given and comparison of in vitro with the in vivo degradation results are made. (Author)

Descriptors :   (*ADHESIVES, ACRYLIC RESINS), (*ACRYLIC RESINS, CHEMICAL REACTIONS), DEGRADATION, POLYMERIZATION, PHYSICAL PROPERTIES, NITRILES, POLYMERS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, POLYMERIZATION, REACTION KINETICS, TISSUES(BIOLOGY)

Subject Categories : Medical Facilities, Equipment and Supplies
      Polymer Chemistry
      Adhesives, Seals and Binders

Distribution Statement : APPROVED FOR PUBLIC RELEASE