Accession Number : AD0637564

Title :   RIBO NUCLEIC ACID CHEMISTRY: A MODEL SYSTEM FOR RIBONUCLEIC ACID DEPOLYMERIZATION AND HYDROLYSIS.

Descriptive Note : Scientific rept. 1 Nov 61-30 Jun 66.

Corporate Author : GEORGIA INST OF TECH ATLANTA SCHOOL OF CHEMISTRY

Personal Author(s) : Cox,James R. , Jr

Report Date : 30 JUN 1966

Pagination or Media Count : 5

Abstract : The report summarizes evidence based on the kinetic behavior of ribonucleic acid model systems that a strong stereoelectronic effect operates in nucleophilic attack on phosphorus. The origin of this effect was ascribed to the geometric requirements of pl bond formation pi between phosphorus and oxygen. This theory was investigated by X-ray diffraction studies of the moleuclar structure of a suitable compound. (Author)

Descriptors :   (*RIBONUCLEIC ACIDS, DECOMPOSITION), HYDROLYSIS, REACTION KINETICS, MOLECULAR ORBITALS, CHEMICAL BONDS, X RAY DIFFRACTION, MOLECULAR STRUCTURE, PHOSPHORUS, ENZYMES

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE