Accession Number : AD0638788

Title :   MORPHOLOGICAL AND BIOCHEMICAL EFFECTS OF CLOSTRIDIUM PERFRINGENS ALPHA TOXIN ON INTACT AND ISOLATED SKELETAL-MUSCLE MITOCHONDRIA.

Descriptive Note : Technical rept., Aug 65-Apr 66.

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Grossman,I. William ; heitkamp,Dale H. ; Sacktor,Bertram

Report Date : SEP 1966

Pagination or Media Count : 19

Abstract : Electron-dense deposits were observed in skeletal-muscle mitochondria exposed in vivo and in vitro to a partially purified Clostridium perfringens alpha toxin. Depressed oxidative functions in the toxin-exposed, isolated mitochondria were concomitant with the electron-dense deposits. The mitochondria are suggested as the cellular site of action of the alpha toxin. (Author)

Descriptors :   (*MITOCHONDRIA, TOXINS AND ANTITOXINS), (*CLOSTRIDIUM PERFRINGENS, TOXINS AND ANTITOXINS), (*CYTOCHEMISTRY, *TOXINS AND ANTITOXINS), MUSCULOSKELETAL SYSTEM, IN VIVO ANALYSIS, IN VITRO ANALYSIS, PHOSPHOLIPIDS, HYDROLYSIS, OXIDOREDUCTASES, RABBITS

Subject Categories : Biochemistry
      Toxicology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE