Accession Number : AD0639339

Title :   TOXIC EFFECT OF HIGH OXYGEN PRESSURES ON THE ANIMAL ORGANISM.

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : PIKLADOVITSKII,S. I.

Report Date : 11 AUG 1966

Pagination or Media Count : 23

Abstract : A high oxygen partial pressure has various effects on young white mice depending upon their age. The intraperitoneal, subcutaneous and intracapital introduction of wormtree essence in adult white mice causes the appearance of spasma analogous to the ones which are detected during intravenal injection of the preparatus into dogs. The 'threshold' dosage of wormtree amounts for adult white mice is 0.025 g per 100 g of animal weight. Young white mice react to intraperitobal injection of wormtree differently, depending upon age. An intraperitonael introduction of strychnine solution (1:2000) in white mice causes accidents of typical 'Strychnine' pains. Three age brackets for the irritation of the cortex by electrical and chemical irritants can be established in white mice. In its totality these results confirm the assumption that spasma, which appear in warm blooded animals under the effect of high partial oxygen pressures, are the result of an irritation in the cerebral cortex. (Author)

Descriptors :   (*OXYGEN, TOXICITY), PRESSURE, STRESS(PHYSIOLOGY), THRESHOLDS(PHYSIOLOGY), AGING(PHYSIOLOGY), STRYCHNOS ALKALOIDS, DOSAGE, CONVULSIVE DISORDERS, POISONING, HIGH PRESSURE, BRAIN, PRESSURE BREATHING, CEREBRAL CORTEX, STIMULATION(PHYSIOLOGY), MICE, USSR

Subject Categories : Stress Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE