Accession Number : AD0640635

Title :   ELECTRON MICROSCOPE STUDY ON THE INFECTIOUS AND SERUM HEPATITIS.

Descriptive Note : Final rept. no. 10, Jul 65-Jul 66,

Corporate Author : NARA MEDICAL COLL KASHIHARA CITY (JAPAN)

Personal Author(s) : Yasuzumi,Gonpachiro

Report Date : SEP 1966

Pagination or Media Count : 18

Abstract : Biopsy materials from human liver in cases of serum hepatitis were studied in thin sections with the aid of electron microscopy and x-ray scanning microanalysis or electron probe microanalysis. In all the cases of serum hepatitis, glycogen granules appear always all over the cytoplasm of hepatic parenchymal cells, except for cases in which the cytoplasm is occupied by a large number of hemosiderin granules or ferritin particles. The glycogen granules are characteristically organized into 400 to 700 A rosettes composed of smaller granules approximately 200 A in diameter. The lipofuscin granules are often located in the vicinity of a cell boundary, close to a bile capillary. Dense particles 300 to 350 A in diameter, without being surrounded by a limiting membrane, are found in the cytoplasm of the hepatic parenchymal cell and in the dark inclusion body appearing in the intercellular space in almost all the cases of serum hepatitis, suggesting that they may represent the viral particles of serum hepatitis. (Author)

Descriptors :   (*SERUM HEPATITIS, ELECTRON MICROSCOPY), LIVER, BIOPSY, INFECTIOUS HEPATITIS VIRUS, HEPATITIS VIRUSES, GRANULES, GLYCOGEN, CYTOPLASM, JAPAN

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE