Accession Number : AD0643051

Title :   TRANSMURAL POTENTIAL AND STIMULATED ACID IN INNERVATED RAT STOMACH PERFUSED AT PH 3.0,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Vaughan,B. E. ; Ridley,H. A. ; Cummins,J. T.

Report Date : 07 OCT 1966

Pagination or Media Count : 25

Abstract : Acid was secreted at high rates, reaching 5 to 13 micro mole/min, promptly after subcutaneous injection of 400 micro g of a semipurified gastrin preparation. Application of the 'pH-stat' principle to a continuous luminal perfusion technic showed that stimulated acid secretion was sharply cut off when the perfusion medium was changed rapidly from pH 2.5 to pH 2.1. Sectioning the vagal trunks and their associated fibers in the forestomach area caused an immediate inhibition of stimulated acid secretion, which could not be restored by gastrin reinjection. Potential differences usually decreased from 41 to 36 mv between resting and stimulated acid rates, but this was not an invariable finding. Atropine at doses sufficient to block all receptor sites for inhibition of gastrin potential had no effect on the stimulation of acid secretion by re-injection of gastrin. (Author)

Descriptors :   (*GASTROINTESTINAL SYSTEM, NERVES), (*STOMACH, ACIDS), (*ACIDS, SECRETION), AUTONOMIC NERVOUS SYSTEM, STIMULATION(PHYSIOLOGY), INHIBITION, PH FACTOR, ATROPINE, DOSAGE, CHEMORECEPTORS, NERVE FIBERS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE