Accession Number : AD0643271

Title :   EFFECTS OF MAGNESIUM PEMOLINE ON SHOCK AVOIDANCE CONDITIONING AND ON MOLECULAR NEUROCHEMISTRY.

Descriptive Note : Research rept.,

Corporate Author : YORK UNIV TORONTO (ONTARIO) MOLECULAR PSYCHOBIOLOGY LAB

Personal Author(s) : Gaito,John ; Davison,James H. ; Mottin,James ; Schaeffer,Elisabeth ; Rigler,Joanne

Report Date : 27 OCT 1966

Pagination or Media Count : 20

Abstract : Three experiments were conducted with rats in one way active avoidance conditioning apparatus to determine the effects of magnesium pemoline on this task and on brain neurochemistry. The dependent variables were: number of avoidances, latency, and trial of first avoidance; amounts of RNA, DNA, and proteins; ratios of these three; the specific activity of RNA, protein, and tissue pool fractions; and the relative specific activity of the RNA and protein fractions. Rats fed magnesium pemoline showed enhanced conditioning; a tendency to lower specific activity of the TCA, RNA, and protein fractions; and a tendency to lower relative specific activity of the protein fraction. There was a suggestion that the medial and posterior ventral cortices may play an important role in this type of conditioning. (Author)

Descriptors :   (*LEARNING, BIOCHEMISTRY), (*PROTEINS, BIOSYNTHESIS), (*NUCLEIC ACIDS, LEARNING), CONDITIONED RESPONSE, DEOXYRIBONUCLEIC ACIDS, RIBONUCLEIC ACIDS, BRAIN, MAGNESIUM COMPOUNDS, PSYCHOPHYSIOLOGY, CANADA

Subject Categories : Psychology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE