Accession Number : AD0643985

Title :   EFFECTS OF PSYCHOPHARMACOLOGIC DRUGS UPON SENSORY INFLOW IN NORMAL SUBJECTS, IN PSYCHIATRIC PATIENTS AND IN ANIMALS.

Descriptive Note : Annual rept. no. 2, 1 Oct 65-30 Sep 66,

Corporate Author : UNIVERSIDAD DE LA REPUBLICA MONTEVIDEO (URUGUAY) INSTITUTO DE NEUROLOGIA

Personal Author(s) : Austt,Elio Garcia

Report Date : 04 NOV 1966

Pagination or Media Count : 12

Abstract : Averaged visual evoked potentials are being studied in man and animals by means of a computer of average transients (CAT). Modifications incorporated to this computer are described. Effects of psychotropic drugs upon the averaged visual evoked response (VER) in normal subjects are studied. LSD 25 determined multiplication of the waves. The response amplitude increased during continuous flicker stimulation instead of decreasing as observed in controls. Chlorpromazine reduced VER amplitude both in wakefulness and sleep. Stupour and coma VER was simple, lower amplitude than normals. Stuporous subjects important changes were observed generally in conjunction with modifications in background activity indicative of changes in the level of awareness. Effects of same drugs upon visual inflow along primary and secondary visual pathways were studied in cats. LSD 25 VER changed in pattern as well as in amplitude. An increase in latency of secondary waves was evident. Chlorpromazine provoked an increase of primary response with small doses. Larger doses tended to decrease it and to reach normal amplitude. (Author)

Descriptors :   (*PSYCHOTROPIC AGENTS, VISUAL PERCEPTION), VISION, HUMANS, ANIMALS, RESPONSE(BIOLOGY), STIMULATION(PHYSIOLOGY), CHLORPROMAZINE, SLEEP, LYSERGIC ACIDS, ELECTROENCEPHALOGRAPHY

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE