Accession Number : AD0645109

Title :   INTERACTION OF PROGESTERONE AND ALDOSTERONE WITH RED BLOOD CELLS OF THE RAT.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto,Frank

Report Date : 06 SEP 1966

Pagination or Media Count : 15

Abstract : The interaction of progesterone and aldosterone with red blood cells was studied in an in vitro system by equilibrium dialysis technique. The uptake of progesterone by the erythrocytes is of the order of 70-85 percent of the total steroid in contact with the red blood cell, whereas the uptake of aldosterone is insignificant. Consideration of molar ratios of hemoglobin and steroid and calculations of binding affinity of steroid to hemoglobin suggest that the steroid does not enter into the red blood cells, but could be absorbed at the cells' surface. Studies on the metabolism of progesterone and aldosterone by the red blood cells in vitro show that no metabolites of the two steroids occur. (Author)

Descriptors :   (*STEROIDS, *ERYTHROCYTES), (*PROGESTERONE, ERYTHROCYTES), TRANSPORT PROPERTIES, METABOLISM, CORTICOSTEROID AGENTS, DIALYSIS, EQUILIBRIUM(PHYSIOLOGY), IN VITRO ANALYSIS, HEMOGLOBIN

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE