Accession Number : AD0646498

Title :   TOXIC EFFECT OF HIGH OXYGEN PRESSURES ON THE ANIMAL ORGANISM,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Ivanov,I. M. ; Kraychinskii,B. D. ; Prikladovitskii,S. I. ; Sonin,V. R.

Report Date : 20 SEP 1966

Pagination or Media Count : 24

Abstract : Blood transfusion from an animal subjected to compressed oxygen and showing a series of convulsive seizures did not produce an oxygen poisoning syndrome in the recipient in the small doses employed. At high oxygen pressures an increase in blood sugar is observed which is associated with an intensified muscular activity during the seizures. Thus, the hypothesis of a hypoglycemic character of the convulsions in oxygen poisoning must be discarded. In decerebrated animals (in which the thalamus opticus has not been removed) convulsive seizures in oxygen poisoning are not observed even at 8 atm. of oxygen. It is concluded that that the site of damage of the central nervous system causing the convulsions in oxygen poisoning is the cerebral cortex. Preliminary hedonal anesthesia eliminates convulsive seizures in oxygen poisoning. The anesthesia must be sufficiently deep for this purpose. With a short exposure, the anesthesia produces a favorable outcome. Although the use of hedonal eliminates the seizures, it does not warrant an appreciable extension of the exposure, since a sufficiently prolonged action of compressed oxygen will inevitably produce acute inflammatory manifestations in the lungs causing death. In all cases, hedonal post-anesthesia stops seizures observed after removal from the chamber. However, the outcome of the oxygen poisoning depends on the magnitude of oxygen pressure and on the exposure, the species, and the individual resistance of the experimental animal. At 8 atm. pressure, the outcome is unfavorable, since the seizures recur after prolonged sleep and result in death. (Author)

Descriptors :   (*OXYGEN, TOXICITY), (*CONVULSIVE DISORDERS, THERAPY), POISONING, PATHOLOGY, CENTRAL NERVOUS SYSTEM, BLOOD TRANSFUSION, BLOOD CHEMISTRY, BLOOD, GLUCOSE, HYPOGLYCEMIA, ANESTHESIA, CEREBRAL CORTEX, PRESSURE, LABORATORY ANIMALS, USSR

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE