Accession Number : AD0647148

Title :   DIFFERENTIATION BETWEEN PROTEOLYTIC AND TAME ESTEROLYTIC ACTIVITY IN CROTALUS ATROX VENOM.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Bobbitt,Jesse D. ; Reed,Donald E.

Report Date : 12 DEC 1966

Pagination or Media Count : 18

Abstract : Although Crotalus atrox venom can hydrolyze proteins and arginine esters, these activities are not due to a trypsin-like enzyme. Proteolytic and esterolytic activities have been differentiated by specific inhibition by such compounds as PMSF, DFP, EDTA and 2-mercaptoethanol, and by actual resolution of the venom by DEAE-cellulose chromatography. Preliminary results suggest that the proteolytic activity in the venom may have a limited specificity and that this specificity is quite unlike that of trypsin and plasmin. (Author)

Descriptors :   (*VENOMS, ENZYMES), PEPTIDE HYDROLASES, TRYPSIN, ENZYME INHIBITORS, CHROMATOGRAPHIC ANALYSIS, PLASMIN

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE