Accession Number : AD0647398

Title :   FUNCTION OF CARNITINE IN THE FATTY ACID OXIDASE-DEFICIENT INSECT FLIGHT MUSCLE.

Descriptive Note : Technical rept.,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Childress,Charles C. ; Sacktor,Bertram ; Traynor,David R.

Report Date : JAN 1967

Pagination or Media Count : 26

Abstract : The metabolic function of carnitine in the fatty acid oxidase-deficient flight muscle of the blowfly, Phormia regina, was investigated. It is concluded that, in contrast to mammalian systems, the primary function of carnitine in the flight muscle of the blowfly is not related to the utilization of fats. In this tissue, which contains an active carnitine acetyltransferase, carnitine affects the utilization of carbohydrates due to the formation of acetylcarnitine from acetyl coenzyme A (CoA), which is, in turn, derived from pyruvate. This mechanism is of the greatest physiological importance during the transition from a resting state to an actively contracting muscle. Carnitine had no effect on the metabolism of the flight muscle of the bee, which contains neither carnitine nor the enzyme carnitine acetyltransferase. (Author)

Descriptors :   (*ALKALOIDS, METABOLISM), (*FATTY ACIDS, OXIDATION), (*MUSCLES, ENZYMES), TRANSFERASES, COENZYMES, DIPTERA, FLIGHT, PYRUVATES, MITOCHONDRIA, INSECTS, CONTRACTION

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE