Accession Number : AD0647752

Title :   THE RADIOBIOLOGY OF THE CANCER CELL,

Corporate Author : OAK RIDGE NATIONAL LAB TENN

Personal Author(s) : Upton,A. C.

Report Date : JAN 1959

Pagination or Media Count : 24

Abstract : Through study of the effects of ionizing radiation, fundamental information has been gained about the biology of normal and neoplastic cells and about the process of neoplasia. A variety of disturbances have been observed in irradiated cells, including alterations in metabolism, growth, and differentiation, but existing evidence suggests that the most significant primary action of radiation is on the genetic apparatus of the cell. That radiation-induced genetic effects may initiate tumor formation is highly conceivable; however, some other mechanism seems to be involved in certain instances of radiation carcinogenesis. Whatever the mechanism, the development of malignancy appears to be a complex, multistage process. The material basis for the large variation in radiosensitivity that exists among cells of different types is still poorly understood; however, with increasing knowledge of the mode of action of radiation and of the factors influencing the radiosensitivity of the cell, ways are being found to increase, decrease, and repair radiation injury. These advances hold promise of providing means of enhancing the effectiveness of radiotherapy in the treatment of cancer and of reducing the hazard of radiation as a carcinogenic agent. (Author)

Descriptors :   (*CANCER, *RADIOBIOLOGY), NEOPLASMS, RADIATION EFFECTS, PATHOLOGY, METABOLISM, GROWTH(PHYSIOLOGY), GENETICS, RADIATION INJURIES, RADIOTHERAPY, MITOSIS, CHROMOSOMES, RADIATION HAZARDS, X RAYS, RADIATION DOSAGE

Subject Categories : Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE