Accession Number : AD0650196

Title :   LIVER BIOPSY IN HUMAN LEPTOSPIROSIS.

Descriptive Note : Final rept.,

Corporate Author : SAO PAULO UNIV (BRAZIL) INSTITUTO DE MEDICINA TROPICAL

Personal Author(s) : DE Brito,Thales

Report Date : MAR 1967

Pagination or Media Count : 8

Abstract : Liver biopsies of proved human cases of leptospirosis showed partial disappearance and/or distortion of bile ductules and sinusoidal pole microvilli. The more severe cases showed definite mitochondrial pathology. Enlargement of the intercellular spaces was rarely seen. In leptospirosis there is a non specific cellular injury which could be the result of a toxin. Complete cell necrosis was not prominent, this finding being in accordance with the low level of serum transaminase seen in the disease. (Author)

Descriptors :   (*LEPTOSPIRA, DISEASES), (*LIVER, BIOPSY), LEPTOSPIRA ICTEROHAEMORRHAGIAE, HUMANS, PATHOLOGY, CELL STRUCTURE, MITOCHONDRIA, NECROSIS, ENZYMES, TOXINS AND ANTITOXINS, KIDNEYS, PARASITES, ELECTRON MICROSCOPY, BRAZIL

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE