Accession Number : AD0651687

Title :   THE ANTICOAGULANT EFFECT OF HEMOPHILIC BLOOD: PROLONGATION OF CLOTTING IN A CANINE TRANSMITTER.

Descriptive Note : Final rept., Mar 63-May 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Bairrington,Jarrell D. ; Hampton,James W. ; Bird,Robert M.

Report Date : MAR 1967

Pagination or Media Count : 13

Abstract : The effect of transfusions of hemophilic blood on the clotting time of normal and heterozygous beagles was studied. Donors were normal or homozygous for canine hemophilia (clinically mild Factor VIII deficiency); recipients were normal or heterozygous. The amounts of the transfusions did not exceed 2% of the total blood volume, and no bloods were used which showed red cell incompatibilities. The silicone clotting time of the recipient was measured before and 15, 30, and 60 minutes after the transfusion. There were no significant changes induced by transfusion of normal or hemophilic blood into normal animals. A significant prolongation of the silicone clotting time was consistently noted in one of three heterozygous beagles receiving blood from two different homozygous donors. The recipient showing this reaction had a reduced level of Factor VIII activity. (Author)

Descriptors :   (*BLOOD TRANSFUSION, BLOOD COAGULATION), (*BLOOD COAGULATION, *BLOOD DISEASES), DOGS, BLOOD VOLUME, HEMORRHAGE

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE