Accession Number : AD0652668

Title :   MORPHOLOGICAL CHARACTERISTICS OF THE BRUCELLA VACCINE PROCESS IN GUINEA PIGS UNDER THE CONDITIONS OF RADIATION,

Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s) : Shevtsova,Z. V. ; Grekova,N. A.

Report Date : MAY 1966

Pagination or Media Count : 9

Abstract : The peculiarities of the course of the brucellosis vaccinal process under the conditions of radiation were studied using bacteriological and immunological methods. The results are presented of the morphological investigation, which represent not only an index of the immunological reorganization of the organism, but also the criteria of the benignancy of the vaccinal process. The morphological picture of the organs and lymph nodes in the guinea pigs from the various groups was of the same type regardless of the sequence of irradiation and vaccination and the interval between them. Apparently, during all the combinations the development of morphological changes in response to brucellosis vaccine corresponded with the period of the expressed symptoms of radiation sickness. Here the pathomorphological changes which were observed separately during each of the processes were intensified. Upon the dying away of radiation sickness the organisms responded to the presence of a live vaccine culture of brucella by the development of those changes which are considered a morphological expression of immunogenesis. (Author)

Descriptors :   (*RADIATION EFFECTS, *IMMUNITY), (*BRUCELLA, VACCINES), MORPHOLOGY(BIOLOGY), RADIATION DOSAGE, PATHOLOGY, TISSUES(BIOLOGY), RADIATION SICKNESS, GUINEA PIGS, USSR

Subject Categories : Medicine and Medical Research
      Radiobiology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE