Accession Number : AD0653838

Title :   INFLUENCE OF STORAGE IN ACD-ADENINE ON THE METABOLIC INTERMEDIATES OF HUMAN ERYTHROCYTES.

Descriptive Note : Progress rept., 1 May 66-30 Apr 67,

Corporate Author : LABORATORY FOR COMPARATIVE BIOCHEMISTRY LA JOLLA CALIF

Personal Author(s) : Bartlett,Grant R.

Report Date : 29 MAR 1967

Pagination or Media Count : 27

Abstract : The results of the study of ACD-adenine can be summarized as follows: Ion-exchange chromatographic analyses of the erthyrocyte phosphate compounds were carried out on blood which had been stored in ACD and in ACD-adenine for 0, 2, 4, 6 and 8 weeks. No obvious differences were found between ACD and ACD-adenine in the intermediates of glucose metabolism, nor was there any evidence for the accumulation of any of the components of the pentose shunt in either case. On the other hand, it was confirmed that storage of the blood in ACD-adenine led to a significant elevation of the adenine nucleotides, AMP, ADP and ATP, which was especially striking in the case of ATP late in storage. (Author)

Descriptors :   (*ERYTHROCYTES, PRESERVATION), ANTICOAGULANTS, METABOLISM, PHOSPHATES, ADENINE, ADDITIVES, GLYCOLYSIS, SACCHARIDE PHOSPHATES, NUCLEOTIDES, ADENOSINE PHOSPHATES, STORAGE, CHROMATOGRAPHIC ANALYSIS, VIABILITY

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE