Accession Number : AD0653844
Title : PRESERVATION OF RED CELLS IN THE FROZEN STATE WITH SUGARS AND MACROMOLECULAR ADDITIVES: MECHANISM OF INJURY OF FREEZING.
Descriptive Note : Progress rept. no. 62,
Corporate Author : JOHN S SHARPE RESEARCH FOUNDATION BRYN MAWR PA
Personal Author(s) : Strumia,Max M.
Report Date : 01 JUN 1967
Pagination or Media Count : 31
Abstract : The storage of ACD blood can be extended to eight weeks if the blood is incubated with adenine-inosine at the end of the storage period, when measure of viability is based on the accepted standard of an average survival of 70% or better of radioactivity of Cr51 tagged erythrocytes 24 hours posttransfusion. Evidence is presented suggesting that the absolute increase in ATP following incubation with adenine-inosine may not per se be solely responsible for the increased viability of erthrocytes. (Author)
Descriptors : (*ERYTHROCYTES, PRESERVATION), ANTICOAGULANTS, FREEZING, VIABILITY, STORAGE, ADENINE, TRACER STUDIES, BLOOD TRANSFUSION, ADENOSINE PHOSPHATES, NUCLEOSIDES
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE