Accession Number : AD0653844

Title :   PRESERVATION OF RED CELLS IN THE FROZEN STATE WITH SUGARS AND MACROMOLECULAR ADDITIVES: MECHANISM OF INJURY OF FREEZING.

Descriptive Note : Progress rept. no. 62,

Corporate Author : JOHN S SHARPE RESEARCH FOUNDATION BRYN MAWR PA

Personal Author(s) : Strumia,Max M.

Report Date : 01 JUN 1967

Pagination or Media Count : 31

Abstract : The storage of ACD blood can be extended to eight weeks if the blood is incubated with adenine-inosine at the end of the storage period, when measure of viability is based on the accepted standard of an average survival of 70% or better of radioactivity of Cr51 tagged erythrocytes 24 hours posttransfusion. Evidence is presented suggesting that the absolute increase in ATP following incubation with adenine-inosine may not per se be solely responsible for the increased viability of erthrocytes. (Author)

Descriptors :   (*ERYTHROCYTES, PRESERVATION), ANTICOAGULANTS, FREEZING, VIABILITY, STORAGE, ADENINE, TRACER STUDIES, BLOOD TRANSFUSION, ADENOSINE PHOSPHATES, NUCLEOSIDES

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE