Accession Number : AD0653941

Title :   EFFECT OF INTRARECTAL DEXAMETHASONE ON SERUM FREE 17-OHCS LEVELS.

Descriptive Note : Rept. for 15 May-15 Jun 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Sparberg,Marshall ; Jenson,Robert L. ; Beering,Steven C. ; Shannon,Ira L.

Report Date : APR 1967

Pagination or Media Count : 9

Abstract : The small-volume, water-soluble corticosteroid enema is valuable in treating ulcerative proctitis and mild ulcerative colitis. Approximately one-third of the dose is absorbed into the systemic circulation, an amount sufficient to produce pituitary-adrenal suppression. Dexamethasone (1 mg.) orally or dexamethasone-21-phosphate (2 mg.) administered in 45 ml. of warm tap water as a retention enema to healthy volunteers at 8:00 a.m. produced highly significant depression of the 3:00 p.m. serum 17-hydroxy-corticosteroids compared to controls (P < .01). Interpolation of these acute results to the long-term administration of soluble corticosteroid enemas would suggest that chronic pituitary-adrenal suppression may occur after discontinuation of therapy. (Author)

Descriptors :   (*CORTICOSTEROID AGENTS, CHEMOTHERAPY), PITUITARY GLAND, ADRENAL GLANDS, INHIBITION, DOSAGE, DIURNAL VARIATIONS, PHARMACOLOGY, ADRENOCORTICOTROPIC HORMONE

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE