Accession Number : AD0654290

Title :   EFFECT OF URICOSURIC DRUG ADMINISTRATION ON URIC ACID LEVELS IN UNSTIMULATED PAROTID FLUID.

Descriptive Note : Rept. for 10-30 May 65,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Shannon,Ira L. ; Chauncey,Howard H.

Report Date : APR 1967

Pagination or Media Count : 10

Abstract : Parotid fluid was collected twice daily without exogenous stimulation from 6 healthy young adult males, both before and during a 5-day period of uricosuric drug dosage. A highly significant decrease in serum uric acid concentration was brought about by drug administration and a parallel decrease was found in parotid fluid uric acid concentration and uric acid secretion rate. The mean for serum uric acid decreased from 5.40 to 2.06 mg./100 ml. and parotid fluid uric acid concentration fell from 10.16 to 4.23 mg./100 ml. (morning samples) and 7.29 to 3.90 mg./100 ml. (afternoon samples). (Author)

Descriptors :   (*SALIVA, *URIC ACID), DENTISTRY, BLOOD SERUM, DOSAGE, STIMULATION(PHYSIOLOGY), DRUGS, SECRETION

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE