Accession Number : AD0654292

Title :   RAPID TRANSFER OF CORTISOL FROM THE BLOODSTREAM TO PAROTID FLUID.

Descriptive Note : Rept. for 1 Apr-31 May 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Shannon,Ira L.

Report Date : APR 1967

Pagination or Media Count : 13

Abstract : The time required for injected cortisol to appear in significant quantity in parotid fluid has been determined in healthy young adult males. Following intravenous injection, a significant (P < .01) increase in 17-OHCS concentration in parotid fluid was detectable in samples collected from the time of injection to 5 minutes thereafter. When cortisol was administered intramuscularly, the parotid 17-OHCS concentration increased significantly (P < .01) at 15 minutes after dosage. This rapid transfer of cortisol from the blood stream to parotid fluid suggests that parotid fluid steroid measurements possess potential in monitoring adrenocortical responses of even a fleeting nature. (Author)

Descriptors :   (*SALIVA, CORTICOSTEROID AGENTS), INJECTIONS(MEDICINE), DOSAGE, STEROIDS, ADRENAL CORTEX, PHYSIOLOGY, BLOOD CHEMISTRY, DENTISTRY, RESPONSE(BIOLOGY)

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE