Accession Number : AD0654777

Title :   WALTER REED ARMY INSTITUTE OF RESEARCH ANNUAL REPORT (2ND), 1 JULY 66-30 JUNE 1967,

Corporate Author : STARKS ASSOCIATES INC BUFFALO N Y*

Personal Author(s) : Starks,Fred W.

Report Date : 30 JUN 1967

Pagination or Media Count : 186

Abstract : Fifty-two candidate antimalarials were synthesized. Nearly thirty-five percent of these compounds are new to the chemical literature. All materials were isolated and transmitted in analytical purity. Purity characteristics of the potential antimalarials were given prime consideration to obviate potential clinical variations such as toxicity source or drug efficacy. Each material prepared was purified until its elementary constitution agrees within 0.3% of the theoretical values. Moreover, each compound was demonstrated to be chromatographically homogeneous. Infrared and ultraviolet absorption spectra were compiled for each series of compounds. Normal bench scale equipment up to 22-liter reaction flasks were used for the syntheses. Amounts of candidate drugs submitted ranged from 10 to 4,000 grams. (Author)

Descriptors :   (*ANTIMALARIALS, SYNTHESIS(CHEMISTRY)), PURIFICATION, CHROMATOGRAPHIC ANALYSIS, INFRARED SPECTRA, ULTRAVIOLET SPECTRA, VISIBLE SPECTRA, BAND SPECTRA, ORGANIC SULFUR COMPOUNDS, AMINES, QUINOLINES, NITROGEN HETEROCYCLIC COMPOUNDS, POLYCYCLIC COMPOUNDS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE