Accession Number : AD0655579

Title :   INVESTIGATION OF THE EFFECTS OF ACTIVITY AND ENVIRONMENT ON ATABRINE THERAPY.

Descriptive Note : Final rept.

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date : 23 DEC 1943

Pagination or Media Count : 90

Abstract : The purposes of the research were (1) To determine with each of two recommended suppressive regimens administered to troops during active training: (a) the time required to develop equilibrium plasma atabrine levels; (b) the magnitude of the level in relation to dosage and (c) the variability in levels among individuals on the same regimen. (2) To determine the effect of high initial doses in shortening the time required to reach equilibrium levels. (3) To determine the effects of a simulated jungle climate upon the plasma atabrine levels. (4) To study the rate of reduction of plasma atabrine levels after discontinuing administration of the drug. (5) To study the relationship between the plasma atabrine levels obtained with therapeutic doses and those established previously with suppressive regimens. (Author)

Descriptors :   (*ANTIMALARIALS, PHARMACOLOGY), STATISTICAL ANALYSIS, BLOOD PLASMA, DOSAGE, TROPICAL TESTS, EXCRETION, DEGRADATION, PROTEINS, CINCHONA ALKALOIDS, MILITARY MEDICINE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE