Accession Number : AD0655897

Title :   NEUROPHYSIOLOGICAL STUDIES ON THE OLFACTORY RECEPTIVE MECHANISM.

Descriptive Note : Final rept. no. 1, 21 Jan 66-20 Jan 67,

Corporate Author : GUNMA UNIV MAEBASHI (JAPAN)

Personal Author(s) : Takagi,Sadayuki F.

Report Date : APR 1967

Pagination or Media Count : 36

Abstract : Ionic mechanism of the negative receptor potentials (EOG) was studied in the olfactory epithelium of the frog by substituting Na(+) in bathing Ringer's solution with other ions or chemicals, or by increasing or decreasing K(+) or Ca(++) in the solution. It was found that any of sucrose, Li(+), choline(+), tetraethyl ammonium(+) (TEA) and hydrazine can not replace Na(+) in maintaining the EOGs. When Na(+) and K(+) in Ringer's solution were reversed, the negative EOGs reversed their polarity. Then, the reversed EOGs showed a complete or nearly complete recovery only in normal (Na(+)) Ringer's solution but never in the other solutions. Thus, essential role of Na(+) was proved. In K(+)-free Ringer's solution, the negative EOGs decreased in amplitude after an initial increase. In K(+)-excess Ringer's solution, the EOGs increased in amplitude. Thus, contribution of K(+) to the negative EOGs was proved. Contribution of Cl(-) to the EOGs was ruled out by the selectively depresent action of Ba on the Cl(-) permeability. It is concluded that the negative EOGs are elicited by increase in permeability of the olfactory receptive membrane to Na(+) and K(+), but not to Cl(-). (Author)

Descriptors :   (*SMELL, CHEMORECEPTORS), (*CHEMORECEPTORS, ELECTROPHYSIOLOGY), NERVOUS SYSTEM, IONS, ODORS, ELECTRON MICROSCOPY, ELECTROLYTES(PHYSIOLOGY), PERMEABILITY, PHYSIOLOGY, JAPAN

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE