Accession Number : AD0657022

Title :   IMMUNOLOGIC EVALUATION OF DIMETHYL SULFOXIDE.

Descriptive Note : Final rept.,

Corporate Author : WILFORD HALL HOSPITAL (AIR FORCE) LACKLAND AFB TEX

Personal Author(s) : Hegre,Andrew M. ; Smith,Robert E.

Report Date : JUN 1967

Pagination or Media Count : 10

Abstract : Reports in the literature indicated that dimethyl sulfoxide (DMSO) seemed to permit the passage through the skin of extremely large molecular-size particles. Each day for 42 days, 5 cubic centimeters of a mixture of a 100 per cent solution of DMSO and an equal part of a bovine serum albumin solution were applied to the shaved backs of five rabbits. Sera drawn at 14, 28 and 49 days were studied for evidence of precipitating antibody, and the precipitates were evaluated for total nitrogen content. In addition, 10 patients from the Allergy Clinic of Wilford Hall USAF Hospital and with a clinical history of inhalant allergic disease as well as positive skin tests by the conventional technique were selected for study. They were given drop skin tests on the back with 50 per cent DMSO and a 1:40 antigen concentration. No evidence of skin toxicity was found with the use of a 50 per cent DMSO concentration in the animals or the humans. Therefore, consideration should be given to the potential use of DMSO as an antigen carrier vehicle. (Author)

Descriptors :   (*SULFOXIDES, ANTIGEN ANTIBODY REACTIONS), IMMUNITY, ALLERGIC DISEASES, SERUM ALBUMIN, SKIN(ANATOMY), TOXICITY, TRANSPORT PROPERTIES, IMMUNOLOGY

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE