Accession Number : AD0657797

Title :   WATER INSOLUBLE DERIVATIVES OF PROTEINS WITH BIOLOGICAL ACTIVITY.

Descriptive Note : Final technical rept. 1 Jul 66-30 Jun 67,

Corporate Author : WEIZMANN INST OF SCIENCE REHOVOTH (ISRAEL)

Personal Author(s) : Katchalski,Ephraim

Report Date : 30 JUN 1967

Pagination or Media Count : 20

Abstract : A number of derivatives of papain and chymotypsin were prepared in which the active enzyme was covalently bound to a high-molecular weight carrier (e.g., poly-L-ornithyl papain, poly-L-glutamyl chymotrypsin). A kinetic study was made of these compounds, with particular attention given to pH activity profiles. Papain-collodion membranes were also prepared and were examined with respect to the effect of local gradients of enzyme and substrate on their kinetic activity.

Descriptors :   (*ENZYMES, REACTION KINETICS), (*PAPAIN, REACTION KINETICS), (*CHYMOTRYPSIN, REACTION KINETICS), PROTEINS, PEPTIDES, POLYMERS, SYNTHESIS(CHEMISTRY), PH FACTOR, MEMBRANES, ADSORPTION, NITROCELLULOSE, SUBSTRATES, CONCENTRATION(CHEMISTRY), SOLIDS, ISRAEL

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE