Accession Number : AD0658478

Title :   EFFECT OF VARYING PERIODS OF COLD EXPOSURE ON THE ACTION AND METABOLISM OF HEXOBARBITAL,

Corporate Author : PITTSBURGH UNIV PA SCHOOL OF MEDICINE

Personal Author(s) : Kalser,Sarah C. ; Kunig,Rosemarie

Report Date : 1967

Pagination or Media Count : 20

Abstract : The hypnotic effects of hexobarbital were compared with its rate of in Vitro metabolism in the rat exposed to cold for varying periods of time. With cold exposure of 2 to 3 days, increase of hypnotic potency is not parallel to an alteration of drug metabolism by liver 9000 x g supernatant. For the latter to become reduced, cold exposure has to be extended to 2 to 3 weeks. The most striking finding of this work was the dissociation of hyponotic potency from in vitro drug metabolism during short periods of cold exposure which contrasts with the results from long periods of exposure. (Author)

Descriptors :   (*BARBITURATES, METABOLISM), (*EXPOSURE(PHYSIOLOGY), BARBITURATES), IN VITRO ANALYSIS, PHARMACOLOGY, HEAT PRODUCTION(BIOLOGY), SHIVERING, RATS

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE