Accession Number : AD0658720

Title :   LUNG CHANGES RESULTING FROM PROLONGED EXPOSURE TO 100% OXYGEN AT 550 MM HG.

Descriptive Note : Phase rept.,

Corporate Author : NAVAL AIR DEVELOPMENT CENTER JOHNSVILLE PA AEROSPACE MEDICAL RESEARCH DEPT

Personal Author(s) : Kydd,George H.

Report Date : 17 MAY 1967

Pagination or Media Count : 31

Abstract : Rats exposed to 100% oxygen at 500 mm Hg for 30 days survive and show no respiratory or other difficulty during the exposure. Histological examination of the lung tissue indicates that the blood vessels of the lung have undergone a change in structure during the exposure. The results suggest that the media is eroded as evidenced by thin vessel walls and by streaming of the media into the adventitia. There is also evidence of hypertrophy and/or hyperplasia in the vessel walls. (Author)

Descriptors :   (*OXYGEN, TOXICITY), (*LUNG, PATHOLOGY), PRESSURE BREATHING, RESPIRATION, HISTOLOGY, BLOOD VESSELS, GERM FREE ANIMALS, STRESS(PHYSIOLOGY), RATS

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE