Accession Number : AD0659026

Title :   HOMOGRAFT RESPONSE IN ADULT-THYMECTOMIZED MICE: DEFICIENCY WITH AGING AND AFTER LOW DOSE-RATE GAMMA-IRRADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Davis,William E. , Jr ; Cole,Leonard J.

Report Date : 04 AUG 1967

Pagination or Media Count : 25

Abstract : The homograft response to skin grafts of varying antigenic disparity was measured at 15-20 months of age in mice thymectomized at 8 weeks of age. The response to male isografts was delayed more in thymectomized female recipients than in intact recipients. Exposure of female mice to sublethal X radiation (at 10-11 weeks of age) resulted in a further delay in intact recipients and abrogated the response in the thymectomized recipients. Other intact but aged mice showed a slight impairment of response to skin grafts differing at non-H-2 loci. In thymectomized groups, this impairment was increased. Exposure of both intact or thymectomized mice (at 9 months of age) to 1133 rad of low dose rate gamma-radiation (1.4 rad/hr) resulted in an increased delay in response relative to the nonirradiated groups. In all cases, the non-H-2 grafts were the most affected by radiation and thymectomy. It is concluded: (1) After adult thymectomy, the homograft response becomes deficient in old mice, particularly as regards male or non-H-2 isoantigens. (2) Chronic gamma-irradiation after thymectomy further increases this deficiency, presumably by creating a greater demand for new immunocompetent cells and/or by eliciting defects in their precursors. (Author)

Descriptors :   (*TRANSPLANTATION, *RADIATION EFFECTS), (*IMMUNOLOGY, RADIATION EFFECTS), SKIN(ANATOMY), ANTIGEN ANTIBODY REACTIONS, MICE, AGING(PHYSIOLOGY), THYMUS, EXCISION, GAMMA RAYS, X RAYS

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE