Accession Number : AD0659284

Title :   INCREASED SURVIVAL OF IRRADIATED DOGS GIVEN TYPHOID VACCINE BEFORE OR AFTER IRRADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Ainsworth,Earl J. ; Mitchell,Fred A.

Report Date : 29 SEP 1967

Pagination or Media Count : 30

Abstract : Previous studies showed that Typhoid-Paratyphoid vaccine (TAB) increased survival of irradiated dogs when given 24 hours before irradiation, but not when given 1 hour after irradiation. In extending the studies with dogs treated with TAB 24 hours before irradiation, we observed that lowering the TAB dose from 1.0 ml to 0.5 ml, with the intention of lowering toxicity to the animals, resulted in a smaller increase in survival. The LD50 of 457 R obtained for dogs given 1.0 ml of TAB 24 hours before irradiation was approximately 140 R higher than for normal dogs. The pattern of postirradiation leukocyte counts in TAB-treated dogs was of particular interest. The most salient feature was a transient rise in the number of circulating granulocytes which occurred during the second week after irradiation. Both the extent of the rise and the number of circulating granulocytes after the rise was radiation dose-dependent. Although the rise in granulocytes was quite impressive and could contribute to the animals' survival, the experiments with dogs treated 24 hours after irradiation showed that survival was increased in the absence of the rise. These survival results are discussed in terms of TAB-induced changes in the bone marrow. (Author)

Descriptors :   (*RADIATION EFFECTS, VACCINES), (*SALMONELLA, *VACCINES), LABORATORY ANIMALS, EXPOSURE(PHYSIOLOGY), LEUKOCYTES, GRANULES, TOXICITY, PROTECTION, IMMUNE SERUMS, SURVIVAL(PERSONNEL), BLOOD COUNTS, RADIATION TOLERANCE, BLOOD PLATELETS, TABLES(DATA)

Subject Categories : Radiobiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE