Accession Number : AD0660088

Title :   ANTIBODY RESPONSES TO PENICILLIN IN ANIMALS AND HUMANS.

Descriptive Note : Final rept. Feb 63-Jan 67,

Corporate Author : WILFORD HALL HOSPITAL (AIR FORCE) LACKLAND AFB TEX

Personal Author(s) : Smith,Robert E.

Report Date : JUN 1967

Pagination or Media Count : 14

Abstract : Mortality related directly to an allergic reaction to penicillin has been associated with anaphylactic shock. Prevention depends upon withholding penicillin from patients with a history of such allergic reactions. In the present study an antigen formed by coupling 6-amino penicillanic acid to human serum albumin by m-xylidine-diisocyanate has sensitized guinea pigs to penicillin routinely, demonstrated by skin tests and gel diffusion. Sixty-nine patients have been skin tested to the human serum albumin-penicillin complex and to crystalline penicillin G. Twice as many patients had a positive reaction to the complex as to the penicillin G. Three patients who had had a definite reaction to penicillin three weeks prior to testing showed a 20 mm or larger wheal and flare to the complex, whereas only one showed a 10 mm wheal and flare reaction to penicillin G. The antigen formed by coupling penicillin to human serum albumin by diisocyanate is more potent for sensitizing guinea pigs to penicillin and for skin testing humans for penicillin sensitivity than penicillin G or penicillin G absorbed onto human serum albumin. (Author)

Descriptors :   (*PENICILLINS, ALLERGIC DISEASES), (*ANTIGEN ANTIBODY REACTIONS, PENICILLINS), RESPONSE(BIOLOGY), ANAPHYLAXIS, SHOCK(PATHOLOGY), IMMUNITY, SENSITIVITY, IMMUNE SERUMS, SERUM ALBUMIN, GUINEA PIGS, HUMANS, PHARMACOLOGY

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE