Accession Number : AD0661094

Title :   LASER RADIATION EFFECTS ON THE MORPHOLOGY AND FUNCTION OF OCULAR TISSUE.

Descriptive Note : Annual rept., no. 1,

Corporate Author : HONEYWELL INC ST PAUL MINN RESEARCH DEPT

Personal Author(s) : Jones,Arthur E. ; Fairchild,David D.

Report Date : AUG 1967

Pagination or Media Count : 52

Abstract : A study was made of the effects of laser radiation on the structure and function of the primate retina. The program encompasses the ocular effects of pulsed and CW laser radiation through: (1) Anatomical studies of laser-exposed and non-exposed tissue at the resolution of both light and electron optics. These are directed toward studies of the chemical morphology of retinal structures through enzyme and other staining techniques. (2) Analysis of bioelectric potentials in the visual system. The electroretinogram recorded from the intact eye is used to follow long-term effects of laser radiation. The LERG (localized electroretinogram) will be used to study localized effects of laser radiation. Single unit recording from the fourth-order neurons (LGN) of the visual system will be used to study photochemical effects of laser radiation. (3) Laser-induced changes in retinal metabolism are being investigated through autoradiographic studies of C14 labeled vitamin A. (4) Laser exposures of the macula of rhesus and mangabey monkeys are made in conjunction with ERG studies. These animals are trained to perform in testing apparatus and are tested for visual defects. (Author)

Descriptors :   (*LASERS, RADIOBIOLOGY), EYE, TISSUES(BIOLOGY), RETINA, ELECTROPHYSIOLOGY, PATHOLOGY, HISTOLOGY, ELECTRORETINOGRAPHY, NERVE CELLS, BURNS(INJURIES), METABOLISM, AUTORADIOGRAPHY, VISION, PHOTORECEPTORS, MATHEMATICAL ANALYSIS, MONKEYS

Subject Categories : Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE