Accession Number : AD0661206

Title :   THE INFLUENCE OF DIET-INDUCED HYPERPHENYLALANINEMIA ON MOLECULAR NEUROCHEMISTRY AND LEARNING BEHAVIOUR IN THE RAT.

Descriptive Note : Research rept.,

Corporate Author : YORK UNIV TORONTO (ONTARIO) MOLECULAR PSYCHOBIOLOGY LAB

Personal Author(s) : Mottin,James L. ; Gaito,John

Report Date : 20 SEP 1967

Pagination or Media Count : 47

Abstract : Hyperphenylalaninemia was induced in Sprague-Hawley albino rats, either prenatally or at weaning, by dietary overloads of 7% L-phenylalanine. The condition was found to lower brain weights and RNA/DNA, Protein/DNA and Protein/RNA ratios but, except for inducing fatigue, did not appear to interfere with the learning of a 6-unit water-maze task. The brain weight differences and fatigue aspect of the water-maze performance disappeared when the phenylalanine diet was withdrawn, and only residual neurochemical effects remained. In lieu of evidence of a permanent retardation in learning behavior, the neurochemical results cannot be used as an explanation of the mental retardation found in human phenylketonuria. (Author)

Descriptors :   (*PHENYLALANINE, DIET), (*MENTAL DISORDERS, PHENYLALANINE), BLOOD CHEMISTRY, BRAIN, LEARNING, BEHAVIOR, PSYCHOPHYSIOLOGY, PROTEINS, BIOSYNTHESIS, RIBONUCLEIC ACIDS, DEOXYRIBONUCLEIC ACIDS, RATS, HUMANS, CANADA

Subject Categories : Psychology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE