Accession Number : AD0661795

Title :   ULTRASTRUCTURAL STUDIES OF X-RAY INDUCED GLOMERULOSCLEROSIS IN RATS SUBJECTED TO UNINEPHRECTOMY AND FOOD RESTRICTION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Rosen,Victor J. ; Cole,Leonard J. ; Wachtel,Louis W. ; Doggett,Reuben S.

Report Date : 19 SEP 1967

Pagination or Media Count : 30

Abstract : Weanling female Sprague-Dawley rats were utilized to study the effect of undernutrition on the ultrastructure of accelerated irradiation induced glomerulosclerosis. Following uninephrectomy and 2000 rad X-rays to the remaining kidney, a severe, destructive glomerulosclerosis appeared within 7-8 weeks. Food restriction to the point of significant growth retardation resulted in a marked inhibition of the genesis of the glomerular lesion. Ultrastructurally there was marked reduction in all cytoplasm organelles and a striking reduction in mesangial matrix deposition. These observations show that food restriction retards the development of manifestation of what is considered to be a direct radiation effect on the kidney; and add further confirmation to the thesis that a stimulus for growth, combined with the direct effects of radiation accelerates the development of glomerulosclerosis, while growth retardation has a profound inhibiting effect on the evolution of the lesion. (Author)

Descriptors :   (*RADIATION EFFECTS, *KIDNEYS), PATHOLOGY, FOOD, INGESTION(PHYSIOLOGY), EXCISION, GROWTH(PHYSIOLOGY), DIET, X RAYS, RADIATION INJURIES, RADIATION DOSAGE, INHIBITION, ELECTRON MICROSCOPY, CYTOLOGY, RADIOBIOLOGY

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE