Accession Number : AD0661978

Title :   GROWTH OF THE YOUNG MALE RAT IN A HYPEROXIC ENVIRONMENT.

Descriptive Note : Rept. for Sep 66-Apr 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Bartek,Methodius J. ; Daniels,Murphy B. ; Ulvedal,Frode

Report Date : SEP 1967

Pagination or Media Count : 27

Abstract : Young male rats were maintained continuously in a hyperoxic environment for periods up to 8 weeks. During this time, the animals were subjected to an oxygen partial pressure of 369 mm. Hg (97.1%) at a simulated altitude of 380 mm. Hg (18,000 ft). The parameters chosen to delineate growth and development in the rat were: total body weight gain; weight gain of the liver, kidney, testis, spleen, lung, adrenal, heart, and brain; deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein content of these organs; incorporation of 14C-leucine into liver protein; and serum lactate dehydrogenase (LDH) isozymes. In spite of the changes reported in the text, the animals grew well in this atmosphere; however, it should be noted that several fundamental changes were observed in the growth and development on the cellular level. (Author)

Descriptors :   (*OXYGEN, TOXICITY), GROWTH(PHYSIOLOGY), BODY WEIGHT, TISSUES(BIOLOGY), DEOXYRIBONUCLEIC ACIDS, RIBONUCLEIC ACIDS, PROTEINS, BIOSYNTHESIS, OXIDOREDUCTASES

Subject Categories : Stress Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE