Accession Number : AD0662609

Title :   VALIDITY OF THE HUMAN 17-HYDROXYCORTICOSTEROID/CREATININE RATIO.

Descriptive Note : Final rept. Apr 66-May 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Hale,Henry B. ; Shannon,Ira L.

Report Date : SEP 1967

Pagination or Media Count : 13

Abstract : Short-term and long-term trends for urinary creatinine excretion rate, 17-hydroxycorticosteroid (17-OHCS) excretion rate, and the 17-OHCS/creatinine ratio were investigated, utilizing data obtained from 11 healthy men during forenoon and afternoon periods on 5 consecutive days in each of 4 consecutive weeks. Creatinine excretion rate did not show significant forenoon-afternoon variation, but there was forenoon-afternoon variation (P < .01) for both 17-OHCS excretion rate and the 17-OHCS/creatinine ratio, each declining as time proceeded. Using creatinine as the base for 17-OHCS did not cause distortion; instead, there was a statistical gain, as the variance was then lessened. Significant week-to-week variation was detected only in afternoon data, and it was limited to creatinine excretion rate (P < .001) and 17-OHCS excretion rate (P < .01), both declining progressively over the 4-week test period. Since the 17-OHCS/creatinine ratio did not show week-to-week variation, it was concluded that creatinine acted as a correction factor, eliminating the long-term variation in 17-OHCS. (Author)

Descriptors :   (*CORTICOSTEROID AGENTS, EXCRETION), (*KETONES, EXCRETION), NITROGEN HETEROCYCLIC COMPOUNDS, PERIODIC VARIATIONS, STEROIDS, DIURNAL VARIATIONS, STATISTICAL ANALYSIS, METABOLISM

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE