Accession Number : AD0662699

Title :   THE EFFECTS OF HYALURONIDASE ON THE IMMOBILIZATION OF GOATS BY INTRA MUSCULAR SUCCINYLCHOLINE CHLORIDE.

Descriptive Note : Technical rept.,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Ward,F. Prescott ; Swaim,Steven F. ; Chadwick,Ralph D. ; Raulston,Gilbert L. ; Ohanesian,Nicholas

Report Date : DEC 1967

Pagination or Media Count : 18

Abstract : The effects of hyaluronidase on the absorption of intramuscular succinylcholine chloride in goats are discussed. Twenty-five mature, mixed-strain dairy goats were immobilized with 0.33 mg/kg of the drug. An additional 25 goats were given corresponding doses to which hyaluronidase (150 NF units per vial of succinylcholine) had been added. The latent period (the time from injection to collapse) is reduced by 25% in goats given the drug-enzyme mixture. It is concluded that hyaluronidase increases the rate of absorption of succinylcholine chloride. However, it produces no significant difference in the duration of paralysis. (Author)

Descriptors :   (*SKELETAL MUSCLE RELAXANTS, ABSORPTION), ENZYMES, GOATS, PARALYSIS, CHOLINESTERASE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE