Accession Number : AD0662873

Title :   CHARACTERIZATION AND CLASSIFICATION OF THE LIGHT CHAIN COMPOSITION OF A MACROMOLECULAR CRYOPRECIPITATING FACTOR,

Corporate Author : AEROSPACE MEDICAL LAB (CLINICAL) LACKLAND AFB TEX

Personal Author(s) : Gams,Richard A. ; Costanzi,John J. ; Coltman,Charles A. , Jr

Report Date : AUG 1967

Pagination or Media Count : 13

Abstract : Several patients were reported to have a form of cryoglobulinemia in which the IgM protein precipitated in the complex with the IgG protein. In certain instances, the light chains of the IgM were of both kappa and lambda types. In one previous instance, the light chains were exclusively kappa type and in another, exclusively lambda type. The IgM-IgG complex from a patient with a mixed form of cryoglobulinemia was studied. The IgM portion was found to be necessary for the formation of the complex. Pooled human IgG could be substituted for the IgG of the patient. The IgM protein had exclusively kappa type light chains, whereas the IgG portion had light chains of mixed kappa and lambda types. It was concluded that the IgM was an abnormal monoclonal paraprotein that formed a cryoglobulin with the available normal IgG. (Author)

Descriptors :   (*GLOBULINS, CLASSIFICATION), SEPARATION, AGGLUTININS, CHROMATOGRAPHIC ANALYSIS, DISEASES, BLOOD DISEASES

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE