Accession Number : AD0664210

Title :   EFFECT OF HYPOXIA ON MYOCARDIUM IN HEART-LUNG PREPARATION,

Corporate Author : NAVAL AEROSPACE MEDICAL INST PENSACOLA FLA

Personal Author(s) : Nelad,N. S. ; Ogden,Eric

Report Date : 13 NOV 1967

Pagination or Media Count : 18

Abstract : Starling heart-lung preparations were ventilated with various mixtures of oxygen, nitrogen, and carbon dioxide, and the performance of the heart was evaluated by relating stroke work to left atrial pressure. At oxygen tensions of arterial blood between 65 mm Hg and 25 mm Hg performance improved. At 20 mm Hg or lower the performance was impaired but the impairment was reversible. The impairment was accompanied by an accumulation of lactate and pyruvate in the blood which also was reversible as oxygen tension was restored. Possible mechanism of these changes is discussed. (Author)

Descriptors :   (*HYPOXIA, *HEART), BLOOD CIRCULATION, RESPONSE(BIOLOGY), PRESSURE, OXYGEN, NITROGEN, CARBON DIOXIDE, LACTATES, PYRUVATES, CARBOHYDRATES, METABOLISM, BLOOD PRESSURE, IN VITRO ANALYSIS, CARDIOVASCULAR SYSTEM

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE