Accession Number : AD0664676

Title :   ELEVATED PLASMA DEOXYCYTIDINE LEVELS IN RATS: A BIOLOGIC DOSIMETER OF X RADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Guri,Charles D. ; Swingle,Karl F. ; Cole,Leonard J. ; Bailey,J. Stanley

Report Date : 09 FEB 1968

Pagination or Media Count : 18

Abstract : Deoxycytidine (CdR) was identified as the major deoxynucleoside present in normal rat blood plasma, at basal levels ranging from 5.2 - 7.8 micrograms/cc. The separation procedure involved charcoal absorption and paper chromatography (butanol-H2O-NH3 system), and quantitative estimation was carried by the isotope dilute method, employing CdR-2-C14. Significant increases in plasma CdR levels (25-50% over normal) were observed 2 or 3 hours following exposures to 25 R, 33 R, and 50 R of whole-body X radiation. A curvilinear dose-response relationship was evident in the range of 50 R to 200 R, while the response was essentially flat between 200 R and 600 R. The significance of these findings as a basis for a biologic dosimeter for radiation exposure, is discussed. (Author)

Descriptors :   (*RADIATION EFFECTS, NUCLEOSIDES), DOSIMETERS, X RAYS, BLOOD PLASMA, QUANTITATIVE ANALYSIS, BLOOD CHEMISTRY, RADIATION DOSAGE, RESPONSE(BIOLOGY), WHOLE BODY IRRADIATION

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE