Accession Number : AD0664900

Title :   EFFECTS OF MONOMETHYLHYDRAZINE ON LIVER GLYCOGEN CONTENT OF RATS AT GROUND LEVEL AND AT ALTITUDE.

Descriptive Note : Rept. for Sep 65-Jan 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Brown,Lawrence E. ; Scott,Walter N.

Report Date : SEP 1967

Pagination or Media Count : 13

Abstract : Histologic sections of liver samples taken at altitude and ground level from rats having received monomethylhydrazine (MMH), 46.4 mg./kg., were stained for glycogen. Results revealed that nonfasted MMH-injected animals maintained at altitude (18,000 ft.) contained a decreased content of intracellular liver glycogen. The livers of nonfasted rats injected at ground level did not manifest changes in glycogen content. The hepatic glycogen content of the fasted MMH-injected rats (both ground level and altitude) did not differ from that of the controls. Chemical analyses revealed a decrease in hepatic glycogen in rats fed at altitude and an increase in rats fasted at altitude. (Author)

Descriptors :   (*METHYL HYDRAZINES, TOXICITY), GLYCOGEN, LIVER, HISTOLOGY, ALTITUDE, METABOLISM, CHEMICAL ANALYSIS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE