Accession Number : AD0665664

Title :   AN IMMEDIATE IRRADIATION EFFFECT ON RESISTANCE OF RATS TO LOW TEMPERATURE,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Phillips,Richard D. ; Kimeldorf,Donald J.

Report Date : 04 JAN 1968

Pagination or Media Count : 22

Abstract : A study was made of the effect of whole-body X-irradiation (50-2000 rads) on the resistance of male rats exposed to a low environmental temperature (-17.0 plus or minus 1C). The animals were subjected to the test environment at 1/2, 4, 8, 16, or 24 hours after irradiation. A change in resistance was observed after irradiation with doses of 100 rads or more. Irradiation had a detrimental effect on the survival of rats exposed to low temperature at all times tested. The radiation-induced decrease in cold resistance was greater in groups tested early after irradiation than in groups tested at 16 or 24 hours postirradiation. The magnitude of the radiation effect was dose dependent. At doses greater than 100 rads, the median survival time of rats in the cold was inversely related to radiation dose. (Author)

Descriptors :   (*RADIATION EFFECTS, *HEAT PRODUCTION(BIOLOGY)), WHOLE BODY IRRADIATION, COLD WEATHER TESTS, LOW TEMPERATURE, RESISTANCE(BIOLOGY), RADIATION DOSAGE, STRESS(PHYSIOLOGY), AGING(PHYSIOLOGY), BODY WEIGHT, SURVIVAL(PERSONNEL), RESPONSE(BIOLOGY)

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE