Accession Number : AD0665675

Title :   SURVIVAL OF RATS EXPOSED TO 10 PSIA OXYGEN TO FURTHER EXPOSURE AT ONE ATMOSPHERE OXYGEN.

Descriptive Note : Phase rept.,

Corporate Author : NAVAL AIR DEVELOPMENT CENTER JOHNSVILLE PA AEROSPACE MEDICAL RESEARCH DEPT

Personal Author(s) : Kydd,George H.

Report Date : 29 DEC 1967

Pagination or Media Count : 21

Abstract : A rather sharp difference in the effects of exposure to 100% oxygen occurs at around 600 mm Hg PO2 in that pressures slightly higher cause death in most small laboratory animals whereas most animals survive slightly lower pressures. The present experiments were designed to indicate whether there is a relationship between exposures at the lower and higher pressures. The results show that a large percentage of rats pre-exposed at 516 mm Hg (2/3 atmosphere) survive subsequent exposure at PO2 of one atmosphere (714 mm Hg) indicating that a non-additive relationship exists. (Author)

Descriptors :   (*OXYGEN, TOXICITY), BAROMETRIC PRESSURE, LUNG, BLOOD VESSELS, PHAGOCYTES, EDEMA, LYMPHATIC SYSTEM, BLOOD PRESSURE, RATS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE