Accession Number : AD0665839

Title :   HASTENING RESPIRATORY ACCLIMATIZATION TO ALTITUDE WITH BENZOLAMIDE.

Descriptive Note : Final rept. for Oct 66-May 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Kronenberg,Richard S. ; Cain,Stephen M.

Report Date : 28 JUL 1967

Pagination or Media Count : 15

Abstract : A 'double-blind' study involving 72 hours' exposure to a pressure altitude of 14,000 feet (447 torr) was carried out on 23 subjects to ascertain whether benzolamide (CL 11,366) hastened respiratory acclimatization to altitude better than did acetazolamide, another carbonic anhydrase inhibitor previously investigated. Samples of arterial blood, plasma, and cerebrospinal fluid (CSF) were taken at 24 and 72 hours at altitude and analyzed for pH, PCO2, PO2, CO2 content, HCO3-, standard HCO3-, lactate, Na(+), K(+), and Cl(-). End-tidal PCO2, was measured frequently during waking hours, and CO2 response curves were measured daily. Three 24-hour urine collections were analyzed for Na(+), K(-), Cl(-), and 17-hydorxy-corticosteroids. Subjects filled out questionnaires to evaluate their subjective responses to altitude and were ranked by an observer according to their apparent state of well-being. Changes in physiologic variables were consistent with more rapid respiratory acclimatization, and the subjective data indicated that the drug was helpful in ameliorating acute altitude sickness. Benzolamide was not clearly better in either respect than acetazolamide. (Author)

Descriptors :   (*ACCLIMATIZATION, *ENZYME INHIBITORS), HYPOXIA, BLOOD ANALYSIS, CEREBROSPINAL FLUID, BLOOD CHEMISTRY, ELECTROLYTES(PHYSIOLOGY), CORTICOSTEROID AGENTS, RESPONSE(BIOLOGY), RESPIRATION, HIGH ALTITUDE, QUESTIONNAIRES, STRESS(PHYSIOLOGY)

Subject Categories : Anatomy and Physiology
      Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE