Accession Number : AD0666421

Title :   EFFECT OF AN ENZYME CHEWING GUM ON WHOLE SALIVA PROTEASE LEVELS.

Descriptive Note : Rept. for 1 Nov 65-1 Jun 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Shannon,Ira L. ; Segreto,Vincent A.

Report Date : 23 AUG 1967

Pagination or Media Count : 14

Abstract : The release of proteolytic enzymes from a 1.5-gm. bolus of chewing gum containing 12 mg. of Rhozyme P-11 was studied. The chewing of this gum brought about tremendous increases in whole saliva protease levels, followed by a nonlinear decrease in concentration as chewing progressed. The curve that best fits this nonlinear decrease is: y = ab to the x power where y is tyrosine (mg./100 ml. saliva), x is time in minutes after introduction of the fresh stick of gum, and b is less than zero. Subjects responded in essentially the same fashion as each new stick of enzyme-containing gum was introduced. The response across four 30-minute periods with fresh gum was so similar that a single curve adequately described the response: log y = 3.1968 - .049827 (x). On the basis of this equation, it could be predicted that chewing a single stick of this enzyme gum would maintain the salivary protease concentration at a level higher than the control level for approximately 50 minutes. (Author)

Descriptors :   (*PEPTIDE HYDROLASES, *SALIVA), STIMULATION(PHYSIOLOGY), SECRETION, RESPONSE(BIOLOGY), EQUATIONS, CALCULI, MOUTH, DISEASES, TEETH, STATISTICAL ANALYSIS, DENTISTRY, HYGIENE

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE