Accession Number : AD0666713

Title :   USE OF CHROMOSOME ABERRATIONS TO ESTIMATE X-RAY AND GAMMA-RAY DOSE TO MAN.

Descriptive Note : Technical rept. Sep 65-Aug 66,

Corporate Author : CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE

Personal Author(s) : Norman,Amos ; Sasaki,Masao S. ; Ottoman,Richard E. ; Veomett,Robert C.

Report Date : DEC 1967

Pagination or Media Count : 24

Abstract : The frequency of chromosome aberrations in lymphocytes taken from the peripheral blood provides a useful measure of absorbed dose. The estimation of dose is affected by time in culture of the lymphocytes, by sampling error and sampling time, and by size, rate, distribution, and quality of radiation dose. Data on the effect of these variables are presented. Dose is estimated for five people accidentally exposed to ionizing radiation. Four appendixes give a detailed account of optimal technics for making chromosome preparations, the yields of aberrations as a function of dose in 50-hour and 72-hour cultures, and the yield of acentric fragments per dicentric. (Author)

Descriptors :   (*RADIOBIOLOGY, CHROMOSOMES), (*CHROMOSOMES, ANOMALIES), RADIATION DOSAGE, X RAYS, GAMMA RAYS, LYMPHOCYTES, RADIATION EFFECTS, SAMPLING, CULTURE MEDIA

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE