Accession Number : AD0666924

Title :   DEXAMETHASONE-INDUCED PITUITARY-ADRENAL SUPPRESSION AS MEASURED BY PAROTID FLUID STEROID LEVELS.

Descriptive Note : Rept. for May-Jul 66,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Jenson,Robert L. ; Shannon,Ira L. ; Sparberg,Marshall ; Beering,Steven C.

Report Date : DEC 1967

Pagination or Media Count : 11

Abstract : Dexamethasone-21-phosphate (2 mg.) administered to healthy volunteers as a retention enema at 8:00 a.m. produced significant depression of serum and parotid fluid free 17-hydroxycorticosteroids by 3:00 p.m. Measurements of parotid fluid free 17-OHCS may be used to detect changes in adrenocortical function. Pituitary-adrenal suppression may occur after the use of intrarectal soluble adrenal corticosteroids. (Author)

Descriptors :   (*SALIVA, *STEROIDS), PITUITARY GLAND, ADRENAL CORTEX, CORTICOSTEROID AGENTS, INHIBITION, SECRETION

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE